https://ryanorban.com/categories/aging/Recent content in Aging on Ryan OrbanHugoen-usme@ryanorban.com (Ryan Orban)me@ryanorban.com (Ryan Orban)Ryan OrbanFri, 30 Apr 2021 00:00:00 +0000https://ryanorban.com/notes/intermittent-fasting-health-aging-disease-nejm/Fri, 30 Apr 2021 00:00:00 +0000me@ryanorban.com (Ryan Orban)https://ryanorban.com/notes/intermittent-fasting-health-aging-disease-nejm/<h3 id="summary" class="scroll-mt-8 group"> Summary <a href="#summary" class="no-underline hidden opacity-50 hover:opacity-100 !text-inherit group-hover:inline-block" aria-hidden="true" title="Link to this heading" tabindex="-1"> <svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="none" stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" class="lucide lucide-link w-4 h-4 block" viewBox="0 0 24 24" > <path d="M10 13a5 5 0 0 0 7.54.54l3-3a5 5 0 0 0-7.07-7.07l-1.72 1.71" /> <path d="M14 11a5 5 0 0 0-7.54-.54l-3 3a5 5 0 0 0 7.07 7.07l1.71-1.71" /> </svg> </a> </h3> <p>This New England Journal of Medicine review by Rafael de Cabo and Mark Mattson (both NIH) synthesizes decades of animal research and growing clinical evidence for intermittent fasting (IF) as a distinct health intervention. The key reframe: most benefits aren&rsquo;t simply from calorie reduction or reduced oxidative stress — they stem from a specific metabolic switch that occurs when the body depletes liver glycogen and shifts to burning ketone bodies from fat. This switch happens daily or several times per week depending on the fasting protocol.</p>