Subject
2 entries
Cancer
Bookmarks
The Role of Mutations in Epigenetic Regulators in Myeloid Malignancies
Nature Reviews Cancer 2012 paper on the role of epigenetic regulator mutations in myeloid malignancies (AML, MDS, MPN) — summarizing how mutations in DNMT3A, TET2, IDH1/2, EZH2, and others alter the cancer epigenome. A key reference from the early next-generation sequencing era of cancer genomics.
Why We Haven't Cured Cancer: Personalized Medicine vs. Evolution
Science-Based Medicine's argument for why personalized medicine is harder than it looks: tumors are genetically heterogeneous mosaics that evolve under treatment pressure, so targeting a single mutation is like targeting one soldier in an army that reproduces faster than you can shoot. The evolutionary biology of cancer makes resistance nearly inevitable.