Subject
2 entries
Epigenetics
Bookmarks
The Role of Mutations in Epigenetic Regulators in Myeloid Malignancies
Nature Reviews Cancer 2012 paper on the role of epigenetic regulator mutations in myeloid malignancies (AML, MDS, MPN) — summarizing how mutations in DNMT3A, TET2, IDH1/2, EZH2, and others alter the cancer epigenome. A key reference from the early next-generation sequencing era of cancer genomics.
Accurate Identification of RNA Editing Sites from High-Throughput Sequencing Data
A Genomes Unzipped guest post on the bioinformatics challenge of accurately identifying RNA editing sites from high-throughput sequencing data — a technically demanding problem because RNA-DNA differences look similar to sequencing artifacts. Written at the height of the RNA editing research wave.