Subject
3 entries
Pharmacology
Bookmarks
Disulfiram as a Potential Anti-Anxiety Drug
Tokyo University of Science research finding that disulfiram — the alcohol-deterrent drug Antabuse — safely reduces anxiety in rodents, potentially via ALDH2 inhibition affecting acetaldehyde metabolism. Drug repurposing with a well-understood safety profile.
Substitution of Phenylephrine for Pseudoephedrine as a Nasal Decongestant
A medical journal article arguing that replacing pseudoephedrine with phenylephrine in OTC decongestants was an illogical drug policy response to methamphetamine — because phenylephrine is nearly ineffective at the doses sold, while pseudoephedrine actually works.
Algernon's Law — Drug Heuristics
Gwern's formalization of Algernon's Law — the principle that if a cognitive-enhancing drug worked well and was safe, evolution would have selected for the underlying biology already. A useful prior against most nootropic claims, derived from first principles rather than empirical dismissal.