https://ryanorban.com/categories/protein-folding/Recent content in Protein-Folding on Ryan OrbanHugoen-usme@ryanorban.com (Ryan Orban)me@ryanorban.com (Ryan Orban)Ryan OrbanMon, 07 Oct 2013 00:00:00 +0000https://ryanorban.com/notes/gamers-solve-hiv-puzzle-foldit/Mon, 07 Oct 2013 00:00:00 +0000me@ryanorban.com (Ryan Orban)https://ryanorban.com/notes/gamers-solve-hiv-puzzle-foldit/<p><img src="https://ryanorban.com/images/notes/gamers-solve-hiv-puzzle-foldit.png" alt="Gamers Solve Decade-Old HIV Puzzle in Ten Days" class="note-hero-img" loading="lazy" /> </p> <h3 id="summary" class="scroll-mt-8 group"> Summary <a href="#summary" class="no-underline hidden opacity-50 hover:opacity-100 !text-inherit group-hover:inline-block" aria-hidden="true" title="Link to this heading" tabindex="-1"> <svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="none" stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" class="lucide lucide-link w-4 h-4 block" viewBox="0 0 24 24" > <path d="M10 13a5 5 0 0 0 7.54.54l3-3a5 5 0 0 0-7.07-7.07l-1.72 1.71" /> <path d="M14 11a5 5 0 0 0-7.54-.54l-3 3a5 5 0 0 0 7.07 7.07l1.71-1.71" /> </svg> </a> </h3> <p>Foldit is a crowdsourced protein folding game developed by the University of Washington. Players manipulate 3D protein structures through an intuitive game interface, guided by a score that reflects how folded (low-energy, physically plausible) the structure is. In 2011, Foldit players solved the structure of a retroviral protease from Mason-Pfizer monkey virus — an HIV-related enzyme — in about 10 days, cracking a problem that had resisted automated methods and human biochemists for 15 years.</p>